ScienceDirect science article A Rapamycin Activated Caspase 9 Based Suicide Gene May 2 2018 Rapamycin is a safe and widely available immunosuppressive pharmaceutical that acts by heterodimerization of FKBP12 with the FRB fragment of mTOR The apical caspase Author Maria Stavrou Brian Philip Charlotte Traynor White Christopher G Davis Shimobi Onuoha Shaun Co Publish Year 2018
Nature articles s41551 023 01157 4 Cas9 induced targeted integration of large DNA payloads in Dec 13 2023 Here we report a method leveraging the DNA repair pathway homology mediated end joining as well as optimized reagent composition and delivery for the Cas9 induced
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UCL Discovery 1470296 RQR8 A universal safety switch for cellular therapies Following optimisation we established a 136 amino acid construct designated RQR8 composed of two rituximab binding epitopes flanking the QBEnd10 epitope on a CD8 stalk
Ubigene cas9 expressing cell lines Ubigene Cas9 Stable Cell Lines Ad In stock Cas9 stable cell bank Cas9 expression guaranteed High editing efficiency Cas9 testing and STR reports OriGene CRISPR Cas9 CRISPR Genome Editing CRISPR Gene Knockout Kits Ad Ready to use Pre designed kits Complete Kits for CRISPR App 150 Guide RNA Cloning Service CRISPR Cas vectors Order Now Great Values Huge Sample Selection Types cDNA Clones Primary Antibodies Proteins RNAi Vectors CRISPR Cas9 Vectors CRISPR Gene Activation CRISPR Vectors CRISPR Cas Starter Kit
Nature articles s41434 021 00220 6 Targeted multi epitope switching enables straightforward Feb 1 2021 Here we demonstrate for the first time that CD52 can be replaced with the multi epitope safety switch RQR8 in a single step with high efficacy by combining CRISPR Cas9 Author Laura Mosti Lukas M Langner Kay O Chmielewski Patrick Arbuthnot Jamal Alzubi Toni Cathomen Publish Year 2021
Rqr8 Cas9
PubMed 33526841 Targeted multi epitope switching enables straightforward To address these limitations we integrated RQR8 a multi epitope molecule harboring a CD34 epitope and two CD20 mimotopes alongside a CD19 targeting CAR into the CD52 Author Laura Mosti Lukas M Langner Kay O Chmielewski Patrick Arbuthnot Jamal Alzubi Toni Cathomen Publish Year 2021
National Center for Biotechnology Information pmc articles Targeted multi epitope switching enables straightforward Integration of a CAR RQR8 construct is targeted to exon 2 of the CD52 locus Gene targeting by homology direct repair is mediated by a CRISPR Cas9 nuclease in combination Author Laura Mosti Lukas M Langner Kay O Chmielewski Patrick Arbuthnot Jamal Alzubi Toni Cathomen Publish Year 2021 DOI 10 1038 s41434 021 00220 6 Publication Gene Ther 2021 28 9 602 612
Rqr8 Cas9
ResearchGate publication 323661241 A Rapamycin A Rapamycin Activated Caspase 9 Based Suicide Gene ResearchGate Mar 1 2018 Rapamycin is a safe and widely available immunosuppressive pharmaceutical which acts by heterodimerization of FKBP12 with the FRB fragment of mTOR The apical Caspase People also search for Ubigene cas9 expressing cell lines Ubigene Cas9 Stable Cell Lines Ad In stock Cas9 stable cell bank Cas9 expression guaranteed High editing efficiency Cas9 testing and STR reports
National Center for Biotechnology Information pmc articles Development and testing of a versatile genome editing Jun 6 2024 Using adenine BE Cas9 and Cas9 nickase for HDR we compared editing efficiencies by measuring eGFP and NIS signals Transiently expressed SCID A V GEAR had
Cell Press molecular therapy family oncology Development of STEAP1 targeting chimeric antigen receptor for Sep 15 2022 The anti human STEAP1 specific scFv was cloned into retroviral SFG vectors between the NcoI and BamHI restriction sites A plasmid containing the suicide sorter marker
American Society of Hematology blood article A highly compact epitope based marker suicide gene for easier Aug 21 2014 We have created a highly compact marker suicide gene for T cells combining target epitopes from both CD34 and CD20 antigens RQR8 This construct allows selection with